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Abstract #3202

Population-Averaged 7T 1H MRS Determination of Metabolites in Human Skeletal Muscle at Rest

Jimin Ren1, Ivan Dimitrov1,2, Craig R. Malloy1,3, A. Dean Sherry1,4

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Philips Medical System, Cleveland, OH, United States; 3VA North Texas Health Care System, Dallas, TX, United States; 4Department of Texas at Dallas, University of Texas at Dallas, Richardson, TX, United States

Proton MRS offers many advantages for detection of a number of muscle metabolites. However, quantitative and reliable measurement of muscle metabolites can be quite challenging due to multiple factors intrinsic to MRS and skeletal muscle itself. We present here an optimized 1H MRS acquisition protocol, termed muscle module, for acquisition of high-quality spectra for easy data analysis. This muscle module is based on a STEAM sequence, with data acquisition at two different echo-times, TE 140 and 280 ms, without applying water-suppression pulses. Its advantage in spectral resolution enhancement and quantitative analysis is demonstrated in a large population (n = 80).