Abstract #3213

Assessment of T1ρ & T2 Mapping as Biomarkers of Denaturalization in Articular Cartilage with Osteoarthritis: Comparison with Pathological Results After Total Knee Replacement

Yukihisa Takayama¹, Masamitsu Hatakenaka¹, Takashi Yoshiura¹, Hidetoshi Tsushima², Ken Okazaki², Kei Nishikawa³, Makoto Obara⁴, Yukihide Iwamoto², Hiroshi Honda¹

¹Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; ²Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; ³Radiology Center, Kyushu University Hospital, Fukuoka, Japan; ⁴Philips Electronics Japan, Tokyo, Japan

We retrospectively compared T1 and T2 mapping with pathological results in osteoarthritis patients and analyzed their detectability of an early stage of denatured articular cartilage and correlations to the severity of denaturalization. Both mappings are useful to detect mild and moderate denaturalization prior to thinning of the articular cartilage and to assess the severity of denatured articular cartilage. In particular, T1 mapping is more sensitive than T2 mapping to detect early-stage denaturalization and to assess the severity of denaturalization.