Early & Delayed Contrast Enhancement MRI of the Knee

Wei Li¹, Ewa Gliwa¹, Pottumarthi V. Prasad¹

Recent studies had indicated that neo-angiogenesis at the bone-cartilage interface could lead to differences in early enhancement in subjects with OA. In this study, we have evaluated the relationship between the early enhancement in the bone vs. cartilage in healthy subjects and those with OA. We also evaluated any potential correlation between the early and delayed enhancement phases. We did observe a significant correlation between the enhancement in bone and cartilage. Our data suggest minimal differences in the early enhancement in cartilage between subject with OA and controls. There was only a weak correlation between early and delayed enhancement phases.