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Abstract #3266

Quantitative MRI for Muscle Characterisation Initial Comparison of Young Adults with Cerebral Palsy to Normal Subjects

Jonathan James Noble1,2, Sanjay Vijayanathan3, Adam P. Shortland1,3, Geoff D. Charles-Edwards1,3

1King's College London, London, United Kingdom; 2King's College Hospital, London, United Kingdom; 3Guy's & St Thomas' Hospital, London, United Kingdom

The aim of this study was to compare quantitative MRI measurements from Dixon-based imaging and diffusion tensor imaging (DTI) in the calf muscles of young adults with cerebral palsy and healthy volunteers. A higher average percentage fat content was observed for the CP group compared to the ND group, which was significant when all three muscles are combined (p=0.019). The mean ADC value for the CP group was consistently lower for all muscles investigated, and statistically significant for the lateral gastrocnemius (p=0.013) and muscles combined (p=0.009). No significant difference was found between CP and ND subject groups FA values.