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Abstract #3292

An In Vivo MRI & Computational Fluid Dynamic Simulation of Cerebrospinal Fluid Hydrodynamics in the Third Ventricle

Aurelie Picquot1, Francesco Santini2, Jelena Bock3, Philippe Reymond1, Eleonora Fonari4, Bryn Andrew Martin1, Nikos Stergiopulos1

1Laboratory of Hemodynamics & Cardiovascular Technology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; 2Radiological Physics, University of Basel Hospital, Switzerland; 3Department of Radiology, University Hospital Freiburg , Germany; 4Lausanne Center for Biomedical Imaging, Centre Hospitalier Universitaire Vaudois , Switzerland

CFD simulations have provided detailed information about the complex flow and pressure field within the cerebrospinal fluid system. The solutions of these simulations are sensitive to boundary conditions and thus need validation with in vivo measurements. However, validation of 3D CFD flow calculations and MRI CSF flow measurements have been limited to through plane pcMR velocity measurements. Recent advancements in MRI flow measurement technology have enabled fast measurement of the 3D velocity field within the spinal subarachnoid space, superior sagittal sinus, and ventricles of the brain. This study was focused on comparing the results between 3D CFD flow calculations and 7D MRI measurements within the aqueduct of Sylvius and the third ventricle of the brain.