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Abstract #3328

MR Angiography using Fractional Contrast Doses with VIPR & HYPR

Lauren Ashley Keith1, Frank Korosec2, Charles Mistretta1,2

1Medical Physics, UW - Madison, Madison, WI, United States; 2Radiology, UW - Madison, Madison, WI, United States

This work is motivated by concern over the link between gadolinium-based contrast agents and nephrogenic systemic fibrosis in patients with impaired renal function. By exploiting known benefits of both vastly undersampled isotropic projection reconstruction (VIPR) and highly constrained back projection (HYPR), MRA exams of the lower extremities with 1.0 mm isotropic resolution and 7.35 second temporal resolution have been achieved using half and quarter doses of contrast material (0.05 mmol/kg and 0.025 mmol/kg, respectively) in healthy volunteers and patients.