Honglei Zhang1, Alan H. Matsumoto2, Donald Cutlip3, Timothy P. Murphy4, Christopher J. Cooper5, Lance D. Dworkin6, Martin R. Prince1
1Radiology, Weill Cornell Medical College, New York, NY, United States; 2Radiology, University of Virginia, Charlottesville, VA, United States; 3Clinical Investigations, Harvard Clinical Research Institute, Boston, MA, United States; 4Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States; 5Medicine, the University of Toledo, Toledo, OH, United States; 6Department of Medicine, Alpert Medical School of Brown University, Providence, RI, United States
A total of 132 renal MRAs and 64 CTAs were reviewed by MRA/CTA core lab for randomization into Cardiovascular Outcomes of Renal Atherosclerotic Lesions (CORAL) study, of which only 85 (43%) had > 60% stenosis. For the 29 randomized to angioplasty/stent therapy, DSA confirmed that MRA correctly identified 87% lesions as hemodynamically significant. In 77 MRA studies with local reports, core lab readings were consistent with the readings by local radiologist in 39 patients (51%). Local radiologists overestimated renal artery stenosis severity in 29 of 170 arteries and missed 7/16 accessory renal arteries.