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Abstract #3334

Comparison of Renal MRA/CTA & DSA in CORAL Study

Honglei Zhang1, Alan H. Matsumoto2, Donald Cutlip3, Timothy P. Murphy4, Christopher J. Cooper5, Lance D. Dworkin6, Martin R. Prince1

1Radiology, Weill Cornell Medical College, New York, NY, United States; 2Radiology, University of Virginia, Charlottesville, VA, United States; 3Clinical Investigations, Harvard Clinical Research Institute, Boston, MA, United States; 4Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States; 5Medicine, the University of Toledo, Toledo, OH, United States; 6Department of Medicine, Alpert Medical School of Brown University, Providence, RI, United States

A total of 132 renal MRAs and 64 CTAs were reviewed by MRA/CTA core lab for randomization into Cardiovascular Outcomes of Renal Atherosclerotic Lesions (CORAL) study, of which only 85 (43%) had > 60% stenosis. For the 29 randomized to angioplasty/stent therapy, DSA confirmed that MRA correctly identified 87% lesions as hemodynamically significant. In 77 MRA studies with local reports, core lab readings were consistent with the readings by local radiologist in 39 patients (51%). Local radiologists overestimated renal artery stenosis severity in 29 of 170 arteries and missed 7/16 accessory renal arteries.