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Abstract #3375

Time-Evolution of Edema in Reperfused Acute Myocardial Infarction: Implications for Assesment of Area-At-Risk

Veronica L. M. Rundell1, Avinash Kali1, Xiangzhi Zhou1, Ying Liu1, Richard L. Q. Tang1, Andreas Kumar2, Rohan Dharmakumar1

1Radiology, Northwestern University, Chicago, IL, United States; 2Laval University

T2-weighted MRI of acute myocardial infarction (AMI) has been used to determine Area-At-Risk. To investigate the resolution time of edema following ischemia-reperfusion injury, a canine model of reperfused AMI was investigated using both T2 mapping and T2 STIR protocols before and during infarction and again on days 2, 5, 7 and 56 following reperfusion. The percent volume of hyperintense myocardial regions (edema) peaked on day 2 and 5, respectively on T2-STIR images and T2 maps. Hyperintensity resolved to pre-infarct levels by week 8. Imaging approach and time to imaging may be key factors in determining Area-at-Risk and salvagable myocardium.