Bastiaan J. van Nierop1, Tom J. L. Schreurs1,2, Hans C. van Assen2, Gustav J. Strijkers1, Klaas Nicolay1
1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2Biomedical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
Tagged cinematographic MRI using SPAtial Modulation of Magnetization (SPAMM) enables assessment of myocardial tissue displacement in vivo. However, a poorly chosen tag distance may result in inaccurate estimations of displacement. Only a few studies address the question, which tag distance results in the most accurate estimation of displacement. Therefore, this study aimed to determine the optimal SPAMM tag distance to accurately calculate tissue displacement in the mouse left ventricle, using optical flow analysis. It was concluded that the most accurate estimations for in vivo murine myocardial displacements are obtained with tag distances between 1.0 and 1.5 mm, both in healthy and hypertrophied hearts.