Andrea Protti1, Xuebin Dong1, Marcelo Andia2, Sanjay Chaubey1, Bin Yu1, Matthias Taupitz3, Rene Botnar2, Ajay M. Shah1
1Cardiovascular Division, Kings College London BHF Centre of Excellence, London, UK, United Kingdom; 2Division of Imaging Sciences & Biomedical Engineering, Kings College London BHF Centre of Excellence, London, UK, United Kingdom; 3Department of Radiology, Charite-Universitaetsmedizin, Berlin, Germany
Myocardial infarction (MI) represents an acute injury of the myocardium and triggers the recruitment of monocytes and subsequent accumulation of macrophages at the site of injury. Despite intensive research in this field it is still poorly understood how many and which type of monocytes are involved in the migration into the infarct zone. Non-invasive imaging methods is therefore of great interest for the in-vivo investigation of the inflammatory response post MI. In this work, we investigate VSOP for direct imaging of inflammation in a mouse model of MI. We investigated several time points after MI and with different injection protocols.