Abstract #3417

Glutamate & Glutamine Spectroscopic Imaging in Brain Tumors at 3.0 T

Sandeep Kumar Ganji¹, Ivan E. Dimitrov^1,2, Elizabeth A. Maher³, Changho Choi¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; ²Philips Medical Systems, Cleveland, OH, United States; ³Internal Medicine & Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States

Alterations in glutamate (Glu) and glutamine (Gln) levels have been reported in several brain tumors ex-vivo and in vivo. Spectroscopic imaging of Glu and Gln in vivo remains challenging due to spectral overlaps and low signal intensities. Here we report Glu and Gln spectroscopic imaging employing an optimized-TE PRESS-based method. We present the in-vivo data from healthy volunteers and brain tumor patients. The concentration maps of metabolites are reported.