Meng Gu1, Daniel M. Spielman1, Natalie M. Zahr2, Adolf Pfefferbaum2, Edith V. Sullivan2,3, Dirk Mayer1,2
1Radiology, Stanford University, Stanford, CA, United States; 2Neuroscience Program, SRI International, Menlo Park, CA, United States; 3Psychiatry & Behavioral Sciences, Stanford University
Fast spiral spectroscopic imaging based on constant-time-point-resolved spectroscopy, CT-PRESS, has been implemented at 3T for detection of Cho, Cre, mI, Glu, Gln and NAA. To avoid losing spatial coverage from volume selection using PRESS, a robust suppression scheme using multiple dualband frequency-selective RF pulses was applied to simultaneously suppress both water and lipids of different T1s over a 20% range of B1 inhomogeneity. This in vivo human study demonstrated whole brain coverage with effective water and lipid suppression without disturbing signals of metabolites of interest and within an acquisition time suitable for clinical studies.