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Abstract #3424

Absolute Metabolite Quantification by Magnetic Resonance Spectroscopy Imaging in Skeletal Muscle: First Results & Reproducibility

Xin Wang1, Laura Fayad1, Peter Barker2

1Johns Hopkins University, Baltimore, MD, United States; 2Radiology, Johns Hopkins University, United States

The purpose of this study is to report and verify the reproducibility of multi-voxel 2D magnetic resonance spectroscopy imaging (MRSI) for the absolute metabolite quantification in the musculoskeletal system. The phantom replacement method was employed for the absolute quantification of Choline in 5 healthy skeletal muscle groups. Good agreement was achieved for the estimation of Cho concentration in different muscle groups and between different scanning sessions at 2 months apart. MRSI is a promising technique for the metabolic evaluation of musculoskeletal physiology and pathology, by providing large field of view imaging at a high spatial resolution.