Xin Wang1, Laura Fayad2, Peter Barker
The purpose of this study was to compare two different quantitation methods for musculoskeletal (MSK) MRS using phased array coils. The phantom replacement and internal water-referencing methods were compared for determining Choline (Cho) absolute concentration in normal skeletal muscle at 3T. In vivo Cho concentrations were measured by single voxel proton MRS in the quadriceps muscle of eleven volunteers. Excellent agreement between the two techniques was found on testing phantoms, while some discrepancies were observed in vivo.