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Abstract #3436

In-Vivo Short-Echo-Time Single-Voxel Proton LASER Spectroscopy at 7 Tesla Incorporating Macromolecule Subtraction

Jacob Penner1,2, Andrew Lim1, Andrew Curtis1,2, Martyn Klassen1, Joseph Gati1, Matthew Smith3,4, Michael Borrie3,4, Robert Bartha1,2

1Centre for Functional & Metabolic Mapping, Robarts Research Institute, London, Ontario, Canada; 2Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 3Medicine, University of Western Ontario, London, Ontario, Canada; 4Division of Aging, Rehabilitation, & Geriatric Care, Lawson Health Research Institute, London, Ontario, Canada

The purpose of this study was to develop a method for acquiring short-echo-time 1H MRS at 7T. Firstly, data was obtained from the parietal-occipital region of young healthy volunteers using a modified single-voxel LASER sequence. The inversion times TI1/TI2 for optimal metabolite suppression leading to macromolecule detection were found to be 3.14/0.70 s from measured T1s of NAA, Glu, Cr, and Cho (1.34 0.08 s, 1.04 0.09 s, 1.48 0.05 s, and 1.22 0.05 s, respectively). Secondly, the prior knowledge used for fitting in-vivo data was developed including lineshapes from 19 separate aqueous metabolite phantoms.