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Abstract #3449

Towards Standardization of Volumetric MRSI

Andrew A. Maudsley1, Sulaiman Sheriff1, Mohammed Sabati1, Meng Gu2, Juan Wei3, Dan Spielman2, Peter Barker3, Rajesh Garugu1

1Radiology, University of Miami, Miami, FL, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3Radiology, Johns Hopkins University, Baltimore, MD, United States

Implementations of MR spectroscopic imaging vary across sites and instrument manufactures, and are restrictive in terms of the spatial extent over which data is obtained and relative complexity of the data analysis. To address these limitations a volumetric 1H MRSI acquisition has been implemented on instruments from three instrument manufacturers and combined with automated processing procedures. Results indicate comparable performance across all 3 systems and feasibility for multi-site volumetric MRSI studies, with the potential for pooling normative data for reducing costs and increasing sensitivity for clinical studies.