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Abstract #3454

Optimized Semi-LASER 3D MRSI Sequence for Lactate Detection in the Prostate

Thiele Kobus1, Arend Heerschap1, Tom W. J. Scheenen1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands

3D MRSI with adiabatic refocusing pulses was optimized for lactate detection in the prostate. Echo time and inter-pulse delays of the AFP pulses were optimized for an in phase citrate shape and anti-phase lactate signals. Simulations, phantom and in vivo measurements were performed. In 3 patients with advanced prostate cancer lactate signals remained below the minimal detectable lactate levels of around 1 mM.