Meeting Banner
Abstract #3466

Biexponential T2 Approach to Investigate Water Organization & Molecular Mobility of Hydrated HPMC Dosage Forms. Influence of Drug Substances with Different Water Solubility.

Anna Mlynarczyk1, Krzysztof Jasinski1, Piotr Kulinowski1, Marco L. H. Gruwel2, Przemysaw Dorozynski3, Boguslaw Tomanek1,2, Wladyslaw P. Weglarz1

1Department of Magnetic Resonance Imaging, Institute of Nuclear Physics PAN, Krakow, Poland; 2Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, Manitoba, Canada; 3Department of Pharmaceutical Technology & Biopharmaceutics, Jagiellonian University, Krakow, Poland

MRI time-resolved approach was used to measure spatial distribution of T2 and PD of HPMC-based tablets during hydration. Biexponential T2 data analysis approach was used to distinguish regions with different water organization and molecular mobility. Influence of two active substances, that are freely (L-dopa) and poorly (Ketoprofen) soluble on matrix structure during hydration was tested. In all cases hydrated area consists of several separated sub-areas (layers) with well-defined properties: dry-glassy-polymer, infiltration-layer, solid-swollen-layer, gel-layer. Subpixel-level heterogeneity during hydration was clearly visible. In case of Ketoprofen formulation, gel layer area is not present which has great influece on drug dissolution during hydration.