Abstract #3466

Biexponential T2 Approach to Investigate Water Organization & Molecular Mobility of Hydrated HPMC Dosage Forms. Influence of Drug Substances with Different Water Solubility.

Anna Mlynarczyk¹, Krzysztof Jasinski¹, Piotr Kulinowski¹, Marco L. H. Gruwel², Przemysaw Dorozynski³, Boguslaw Tomanek^1,2, Wladyslaw P. Weglarz¹

¹Department of Magnetic Resonance Imaging, Institute of Nuclear Physics PAN, Krakow, Poland; ²Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, Manitoba, Canada; ³Department of Pharmaceutical Technology & Biopharmaceutics, Jagiellonian University, Krakow, Poland

MRI time-resolved approach was used to measure spatial distribution of T2 and PD of HPMC-based tablets during hydration. Biexponential T2 data analysis approach was used to distinguish regions with different water organization and molecular mobility. Influence of two active substances, that are freely (L-dopa) and poorly (Ketoprofen) soluble on matrix structure during hydration was tested. In all cases hydrated area consists of several separated sub-areas (layers) with well-defined properties: dry-glassy-polymer, infiltration-layer, solid-swollen-layer, gel-layer. Subpixel-level heterogeneity during hydration was clearly visible. In case of Ketoprofen formulation, gel layer area is not present which has great influece on drug dissolution during hydration.