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Abstract #3468

Metabolic Regulatory Variation in Rat Serum Due to Cold Stress: High Resolution 1H NMR Approach

Sonia Gandhi1, Hemanth Kumar Bhonsle Somu1, Memita Devi1, Sunil Pal2, Rajendra P. Tripathi1, Subash Khushu1

1NMR Research Centre, Institute of Nuclear Medicine & Allied Sciences, DRDO, Delhi, India; 2Division & Cyclotron & Radiopharmaceutical Sciences, Institute of Nuclear Medicine & Allied Sciences, DRDO, Delhi, India

Prolonged/repeated cold stress is recognized as a risk factor for many disorders including cardiovascular diseases, myocardial infarction, depression, increased sympathetic activity causing neuro-humoral and metabolic changes for adaptation. Present study investigates the changes in metabolic profiles of serum in rats due to prolonged cold stress using NMR & multivariate statistical analysis (PCA). Results shows marked increase in metabolites viz lactate, alanine and glucose on prolonged cold exposure for 15 days indicating changes in carbohydrate and energy metabolism. Noninvasive monitoring of various biochemical pathways can be done & these results can be used to develop strategies to sustain cold stress.