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Abstract #3470

High Resolution 1H NMR Spectroscopy Successfully Discriminates Fetuses with Congenital Diaphragmatic Hernia from Normal Pregnancies

Anca Ramona Croitor Sava1, Veronika Beck2,3, Inga Sandaite4, Jan Deprest2,3, Filip Claus4, Sabine Van Huffel1, Uwe Himmelreich5

1Depart. Electrical Eng. ESAT/SCD, Katholieke Universiteit Leuven, Leuven, Belgium; 2Division Woman & Child, University Hospital Gasthuisberg, Leuven, Belgium; 3Centre for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium; 4Division of Medical Imaging, University Hospital Gasthuisberg, Leuven, Belgium; 5Dept. Medical Diagnostic Sciences Biomedical NMR Unit, Katholieke Universiteit Leuven, Leuven, Belgium

High resolution 1H NMR spectroscopy is performed to compare amniotic fluid from fetuses with congenital diaphragmatic hernia undergoing temporary tracheal occlusion or its reversal against healthy controls. Principle Component Analyses and Multidimensional Scaling are separately applied in combination with various automated classification techniques for differentiating the complicated pregnancies. Results show that dimensionality reduction methods in combination with automated classifiers when analyzing 1H NMR spectra have a high potential in identifying complicated pregnancies. Thus, it can represent an attractive tool which combined with routine fetal magnetic resonance imaging could help to obtain a more detailed picture of the fetal status.