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Abstract #3523

Spectroscopic Imaging of Cerebral Metabolism using Hyperpolarized [1-13C]Pyruvate & Multi-Echo Single-Shot RARE Sequence

Peter Otto Magnusson1, Sadia Asghar Butt1, Mette Hauge Lauritzen1, Jan Henrik Ardenkjr-Larsen2, Per kesson1, Lise Vejby Sgaard1

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 2GE Healthcare, Hillerd, Denmark

Efficient and rapid utilization of available magnetization is of greatest importance in hyperpolarized 13C MR since the in vivo decay time constant of the hyperpolarized signal is less than one minute. Here we demonstrate the potential of a multi-echo single-shot RARE sequence (FSEME) for rapid spectroscopic imaging of cerebral metabolism using HP [1-13C]Pyruvate. A FSEME-sequence was implemented and optimized and in vivo rat head 13C-scanning was conducted. Identification of cerebral sub-structures in metabolite maps from hyperpolarized [1-13C]Pyruvate in the rat brain was for the first time demonstrated using the rapid FSEME spectroscopic imaging sequence.