Mor Mishkovsky1,2, Tian Cheng1,
Rolf Gruetter1,3, Arnaud Comment1,2
1Laboratory for Functional
& Metabolic Imaging , Ecole Polytechnique Fdrale de Lausanne, Lausanne,
Switzerland; 2Department of Radiology, Universit de Lausanne,
Lausanne, Switzerland; 3Department of Radiology, Universits de
Lausanne et de Genve, Lausanne & Genve, Switzerland
In vivo localized and fully adiabatic homo- and hetero-nuclear polarization transfer experiments were designed and performed in the rat brain at 9.4T after infusion of hyperpolarized 13C2 and 1-13C sodium acetate solutions. The new scheme presented herein allows for highly enhanced in vivo detection of nuclear spins with short T1s, including protons, thus bringing new spectroscopic information on hyperpolarized substrates and their metabolites. In addition, in cases of narrow spectral dispersion, indirect detection can improve the spectral resolution such as in the case of 1-13C acetate of 15N choline metabolism.