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Abstract #3532

Free-Breathing Cardiac & Respiratory-Gated Imaging of Hyperpolarized Pyruvate & Bicarbonate in the Heart

Angus Zoen Lau1,2, Albert P. Chen3, Marie A. Schroeder2,4, Wilfred W. Lam2, Yiping Gu2, Jennifer Barry2, Charles H. Cunningham1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 3GE Healthcare, Toronto, ON, Canada; 4Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

We incorporate respiratory gating into a rapid multi-slice single-shot cardiac 13C imaging pulse sequence. This provides time-resolved imaging of hyperpolarized [1-13C]pyruvate, [1-13C]lactate, and 13C bicarbonate in vivo (TR 2.5s, 2 slices, 9 mm in-plane resolution), allowing for capture of the first pass of the tracer bolus and images of downstream metabolites at later times after they have appeared. The sequence is demonstrated in vivo in pig hearts and may provide improved quantitative measurements of 13C metabolism in vivo.