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Abstract #3537

Spectral-Spatial EPI Sequence with Frequency Correction for Dynamic 3D Imaging of Pre-Polarized 13C Metabolites

Charles H. Cunningham1,2, Ralph E. Hurd3, Albert P. Chen4

1Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3GE Healthcare, Menlo Park, CA, United States; 4GE Healthcare, Toronto, ON, Canada

Motivated by the need for 3D metabolic images at multiple timepoints, a rapid spectral-spatial echo-planar imaging (ss-epi) pulse sequence tailored for clinical application was developed. The feasibility of using registration of consecutive metabolic images as a method for measuring and correcting the frequency-induced spatial shifts that occur in vivo was investigated. In experiments with rats and hyperpolarized [1-13C] pyruvate, excellent image quality and apparent agreement with the underlying anatomy was observed. The frequency correction method was shown to have an accuracy of 3 Hz.