Charles H. Cunningham1,2, Ralph E. Hurd3, Albert P. Chen4
1Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3GE Healthcare, Menlo Park, CA, United States; 4GE Healthcare, Toronto, ON, Canada
Motivated by the need for 3D metabolic images at multiple timepoints, a rapid spectral-spatial echo-planar imaging (ss-epi) pulse sequence tailored for clinical application was developed. The feasibility of using registration of consecutive metabolic images as a method for measuring and correcting the frequency-induced spatial shifts that occur in vivo was investigated. In experiments with rats and hyperpolarized [1-13C] pyruvate, excellent image quality and apparent agreement with the underlying anatomy was observed. The frequency correction method was shown to have an accuracy of 3 Hz.