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Abstract #3545

Quantitative BOLD using a Diffusive Model

John David Dickson1, Dmitriy a Yablonskiy2, Alex L. Sukstanskii2, Tom W. J. Ash3, Guy B. Williams3, Richard E. Ansorge1

1Department of Physics, Cambridge University, Cambridge, Cambridgeshire, United Kingdom; 2Mallinckrodt Institute of Radiology, University of Washington in St Louis, St Louis, MO, United States; 3Wolfson Brain Imaging Centre, Cambridge University, United Kingdom

Previous work in quantitative BOLD has made use of a static model of baseline BOLD signal. In order to account for spin diffusion we introduce a recently created phenomenological diffusive BOLD model into the quantitative BOLD method. Applying this to real MRI data we show that estimates of hemodynamic properties in the healthy brain are closer to literature values than achieved when using the static model.