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Abstract #3560

Spontaneous fMRI Activity Reflects a Dynamic Image of Brain State

Marta Bianciardi1, Masaki Fukunaga1, Jacco A. de Zwart1, Jeff H. Duyn1

1Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

The origin of spontaneous fMRI activity (SA-fMRI) of the human brain is still poorly understood, for example if it represents ongoing sensory processing or homeostatic/cognitive functions that depend on brain state. To investigate this, we measured the amplitude of SA-fMRI in the visual cortex and of fluctuations in amplitude of magnetoencephalographic-MEG activity and electro-oculogram-activity, varying independently the brain-attentive-state (eyes-open/closed) and the visual input (presence/absence of light). Amplitude of SA-fMRI changed dynamically with brain state, and was not modulated by visual input. Our results suggest that the level of SA-fMRI may depend on the level of arousal and oculo-motor activity.