Fa-Hsuan Lin1,2, Jonathan R. Polimeni2, Kevin Wen-Kai Tsai1, Thomas Witzel2, Wei-Tang Chang1, Wen-Jui Kuo3, John W. Belliveau2
1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 2Martinos Center, Massachusetts General Hospital, Charlestown, MA, United States; 3Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan
BOLD-contrast fMRI has been widely considered with a poor temporal resolution. Here we investigate the limit of temporal resolution accuracy of BOLD fMRI in human visual system using magnetic resonance inverse imaging (InI) with 10 Hz volumetric sampling rate. Specifically, we interrogate if the inter-hemispheric visual cortex hemodynamic response latency can correctly follow the latency of the visual stimulation between hemifields. We also hypothesize that relative latency in the visual cortex can reliably distinguish between lateralized preceding and the delayed stimuli. Our results suggested that the relative timing accuracy of BOLD response can be as high as 100 ms.