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Abstract #3596

Feasibility of Quantitative Measurements for Regional Cerebral Metabolic Rate of Oxygen (CMRO2) During Functional Change with Visual Stimulus using MRI

Audrey Peiwen Fan1, Jonathan R. Polimeni2, Bruce R. Rosen2,3, Elfar Adalsteinsson1,3

1Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States; 2Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 3Health Sciences & Technology, Harvard-MIT, Cambridge, MA, United States

Phase-based regional oxygen metabolism (PROM) is an MRI method to quantify regional cerebral metabolic rate of oxygen (CMRO2). The technique combines measurements of oxygen saturation (Yv) from MR susceptometry in cerebral veins and local cerebral blood flow (CBF) from arterial spin labeling to estimate regional CMRO2. Using this method at rest and during visual stimulation, baseline CMRO2 in the visual cortex was estimated 15823 μmol/100g/min and increased by 13.1% to 17818 μmol/100g/min with functional activation (p=0.02).