Jochen Rick1, Oliver Speck2, Jrgen Hennig3, Maxim Zaitsev3
1Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, N/A, Germany; 2Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany; 3Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany
Anatomy-related susceptibility gradients in the human head lead to artefacts in echo planar imaging (EPI). The use of a slice-dependent template-based gradient compensation method improves BOLD sensitivity (BS) in areas affected by strong susceptibility-induced field gradients. Here, an evaluation of BS changes is performed for a compensated measurement in relation to an uncompensated measurement. It is shown that the ratio of signal loss to signal gain is well balanced, but the method allows the sensitivity to be optimized in target areas. These results are affirmed in a functional experiment and shows that the method can be used for event-related functional experiments.