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Abstract #3623

Magnetization Transfer fMRI in Humans at 7T

Sung-Yeon Park1, Dae-Hoon Kang1, Se-Hong Oh1, Myoung-Kyun Woo1, Joshua H. Park1, Jun-Young Chung1, Young-Bo Kim1, Zang-Hee Cho1, Seong-Gi Kim2

1Neuroscience Research Institute, Gachon University of Medicine & Science, Incheon, Korea, Republic of; 2Radiology, University of Pittsburgh, United States

Recently a magnetization transfer (MT)-varied fMRI technique was proposed to simultaneously measure stimulus-induced arterial CBV (CBVa) change and BOLD response. In previous 9.4-T animal MT fMRI contradicts to previous 1.5-T human MT studies, in which MT reduced the percentage signal change (i.e., increased MTR). This discrepancy can be due to different magnetic field (9.4 T vs. 1.5 T), different spatial resolution (0.3 mm vs. 3.7 mm), different MT pulse scheme (long CW vs. one short pulse), or different species. Thus, in order to investigate the source of discrepancy, we performed MT fMRI with high spatial resolution in humans at 7 T.