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Abstract #3640

Tumor Induced Alterations in Hemodynamic Responses in BOLD fMRI: Implications in Presurgical Functional Brain Mapping

Liya Wang1,2, Dandan Chen3, Jeffery Olson4, Shazia Ali1, Tianning Fan5, Hui Mao1,2

1Radiology, Emory University School of Medicine, Atlanta, GA, United States; 2Center for Systems Imaging, Emory University, Atlanta, GA, United States; 3Physics, Emory University School of Medicine, Atlanta, GA, United States; 4Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States; 5Center for Systems Imaging, Emory University , Atlanta, GA, United States


The blood oxygenation level dependent (BOLD) fMRI has been widely applied in presurgical planning for brain tumor resection. Growth of brain tumor is commonly accompanied by the abnormal blood perfusion, therefore, may lead to an altered BOLD effect and inaccurate measurement of functional maps. This study investigated the effect of the brain tumor to the HDR and BOLD signal time courses in brain tumor patients and its potential impact to the presurgical brain mapping.