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Abstract #3673

Neurophysiological Underpinnings of Ketamine-Induced Negative BOLD Response & Interactions with Anaesthesia

Naranjargal Dashdorj1, Mirjam I. Schubert1, Malcolm Prior2, Rob Mason3, Dorothee P. Auer1

1Academic Radiology, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Brain & Body Centre, University of Nottingham, Nottingham, United Kingdom; 3School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom

Pharmacological magnetic resonance imaging (phMRI) is an increasingly popular tool to study drug effects on brain function using the blood oxygen level dependent (BOLD) signal. However, the nature of the drug induced BOLD signal change is still not well understood; in particular its relationship with the underlying neural activity. Additionally, the majority of animal phMRI studies require anaesthesia, which may interact with the investigated drug. The neurophysiological underpinnings of BOLD signal changes were directly studied in few hallmark studies. It remains however unclear whether a similar relation between LFP and BOLD signal change exist for pharmacological fMRI under different anaesthetic protocol. In this study we compared ketamine-induced BOLD changes with electrophysiological recordings in rodent brain under two different anaesthetic protocols.