Wolfgang Weber-Fahr1, Alexander Sartorius2, Natlia Gass1, Zhijun Li3, Wolfgang Kelsch2,3
Institute of Mental Health,
It was shown recently in rats that BOLD activation in a particular region can be caused by optogenetic stimulation. In this study we were interested in the hippocampal network in mice and induced expression of channelrhodopsin-2 in Ca2ﷆꖚ蝮阩dependent protein kinase II-expressing neurons by viral injection. Laser stimulation was periodically applied through an optical fiber in the left hippocampus with a block design while fMRI data was aquired. We found activation in a large area of the targeted hippocampus. Interestingly, we also we found a corresponding significant activation in areas outside the stimulated region in the primary somatosensory and motor cortices.