Iris Yuwen Zhou1,2, Y. X. Liang3,
Kevin C. Chan1,2, Matthew M. Cheung1,2, Condon Lau1,2,
K. F. So3, Ed X. Wu1,4
1Laboratory of Biomedical
& Signal Processing, the University of Hong Kong, Hong Kong SAR, China,
People's Republic of; 2Department of Electrical & Electronic
Engineering, the University of Hong Kong, Hong Kong SAR, China, People's
Republic of; 3Department of Anatomy, the University of Hong Kong; 4Department
of Electrical & Electronic Engineering, the University of Hong Kong ,
Hong Kong SAR, China, People's Republic of
Resting-state fcMRI has been increasingly used in the diagnosis of a variety of brain diseases. However, the underlying mechanism of the spontaneous fluctuations in fcMRI signals remains largely unexplored. In this study, we employed a well-controlled animal model of corpus callosotomy to evaluate the role of corpus callosum (CC) in the interhemispheric functional connectivity. It was found that a strikingly loss of interhemispheric correlation after the complete transection of CC while the intrahemispheric connections was preserved and seemed to be expanded. The results of this study provide direct evidence of the role of CC in spontaneous neural activity.
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