Janaki Raman Rangarajan1, Greetje Vande Velde2, Caroline Guglielmetti3, Ruth Vreys3, Marleen Verhoye3, Tom Dresselaers2, Annemie Van Der Linden3, Uwe Himmelreich2, Frederik Maes1
1Medical Image Computing - ESAT/PSI, K.U. Leuven, Leuven, Belgium; 2Biomedical NMR Unit, K.U. Leuven, Belgium; 3Bio-Imaging Lab, University of Antwerp, Belgium
Iron-oxide based particles or MRI reporter genes (e.g. ferritin) can be used for labeling and visualization of endogenous stem cells in the rodent brain. While the quantification of hypo-intense contrast induced by these MRI reporters using parametric T2-maps is often constrained by their low resolution and are sensitive to B1 inhomogeneity, we have developed an image analysis pipeline for regional quantification from 3D T2*-weighted MRI. We demonstrate its potential for in vivo assessment of both iron-oxide particle based and gene based MRI reporters, which creates new opportunities for large scale in vivo imaging studies, including longitudinal follow-up within the same animal.