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Abstract #3910

A Pharmacokinetic Model Enabling Modelling of DCE-MRI Data of Normal & Cancerous Liver

Matthew R. Orton1, David J. Collins1, Martin O. Leach1

1CR-UK & EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom

We present a combined model that describes the contrast enhancement patterns seen in liver tissue and in liver tumours, resulting in a compact but comprehensive methodology enabling voxel-wise fitting over entire liver volumes. By modelling the whole organ a more detailed understanding of liver tumours may be obtained, in particular the complexities surrounding growth and infiltration at tumour boundaries that are particular to metastatic liver disease. The model is demonstrated on DCE-MRI data of a liver containing neuro-endocrine tumours