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Abstract #3917

Variability of Model-Based Blood Volume Correction & Vessel Permeability Estimation in Dynamic Susceptibility Contrast MRI: A Computer Simulation Study

Lin-Wei Hsu1, Yeng-Peng Liao1, Ho-Ling Liu1,2

1Institute of Medical Physics & Imaging Science, Chang Gung University, Taoyuan, Taiwan; 2Department of Medical Imaging & Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Mathematical models have been previously developed to correct for T1 and T2 effects originated from contrast agent extravasations in dynamic susceptibility contrast MRI, and showed additional potentials for assessing the vessel permeability. This study aimed to assess variability of the blood volume (BV) correction and permeability estimation using computer simulations based on varied SNR, permeability and whether baseline T1 is available. The results showed that quality of BV correction and permeability estimation depended on both SNR and severity of contrast agent leakage. Accurate measurement of baseline T1 is especially helpful for the situation of high permeability and low SNR acquisition.