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Abstract #3920

The Effects of Myelin in FA & QSI Indices: Control vs. Long Evans Shaker Rat Brains

Debbie Anaby1, Ian D. Duncan2, Yoram Cohen1

1School of Chemistry, Tel Aviv University, Tel Aviv, Israel; 2School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States

The contribution of myelin on the observed diffusion anisotropy of water in neuronal tissue is not clear. Here we used high-b-value q-space DWI to probe the effects of myelin on diffusion indices in Long Evans shaker (les) and control rat brains. We compared the QSI indices with the FA which was extracted from the low-b-value regime of the QSI data. We found that the QSI indices are significantly different between the groups while the FA blurs the differences between them. Therefore, high b-value QSI should be considered as a means for achieving better distinction between les and control brain tissues.