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Abstract #3924

Tissue Similarity Map of Perfusion Weighted MR Imaging in the Study of Multiple Sclerosis

E. M. Haacke1, Meng Li1, Flavia Juvvigunta1

1Department of Radiology, Wayne State University, Detroit, MI, United States

Multiple Sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. The cerebral perfusion in MS is reduced with the function of severity of the disease. In this study we use a new approach to processing PWI data that we call Tissue Similarity Maps. It can identify those lesions linked by the same vascular response to the contract agent. Our results showed that the TSM of ing the MS lesions is successful in enhancing specifically MS lesions. It is a very useful means to reveal information about tissues otherwise difficult to see with conventional PWI processing approaches.