Abstract #3928

Improved Precision in the Charmed Model of White Matter through Sampling Scheme Optimization & Model Parsimony Testing

Silvia De Santis^1,2, Yaniv Assaf³, Christopher John Evans¹, Derek K. Jones¹

¹CUBRIC, School of psychology, CARDIFF University, United Kingdom; ²Physics Department, Sapienza University, Rome, Italy; ³Tel Aviv University, Israel

We have developed a comprehensive optimised CHARMED pipeline, comprising an optimised data acquisition scheme, based on the electrostatic repulsion algorithm, combined with optimised ordering and extended to different b-value shells, and an analysis approach that incorporates a model parsimony. Marked improvements in data quality are demonstrated using a bootstrap approach. Our proposed pipeline clearly improves the data quality and results in better confidence in the estimated parameters such as fibre orientation.