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Abstract #3928

Improved Precision in the Charmed Model of White Matter through Sampling Scheme Optimization & Model Parsimony Testing

Silvia De Santis1,2, Yaniv Assaf3, Christopher John Evans1, Derek K. Jones1

1CUBRIC, School of psychology, CARDIFF University, United Kingdom; 2Physics Department, Sapienza University, Rome, Italy; 3Tel Aviv University, Israel

We have developed a comprehensive optimised CHARMED pipeline, comprising an optimised data acquisition scheme, based on the electrostatic repulsion algorithm, combined with optimised ordering and extended to different b-value shells, and an analysis approach that incorporates a model parsimony. Marked improvements in data quality are demonstrated using a bootstrap approach. Our proposed pipeline clearly improves the data quality and results in better confidence in the estimated parameters such as fibre orientation.