Electrically Active In-Vitro Spinal Cords for the Study of
Functional Diffusion Weighted Imaging
Nitzan Tirosh1, Uri Nevo1
1Biomedical Engineering, TelAvivUniversity, Tel Aviv,
DWI is explored in the last years as a tool for
imaging brain activity. However the actual interaction between brain function
and water is not yet understood and intensive investigation is therefore
needed. We suggest the use of isolated and perfused spinal cords of newborn
rats as a novel model for the study of the response of vital, mammalian
neuronal tissues in the MRI simultaneously to electrical activity recording.
This model enables to acquire high resolution and high SNR images and good
ADC maps while extracting out multiple physiological factors that are not
related to the neuronal mechanisms under question.