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Abstract #3957

Neuroregenerative Effect of Mesenchymal Stem Cell Following Hypoxia-Ischemia in the Pup Mouse Brain Assessed by Diffusion Tensor Imaging

Yohan van De Looij1,2, Cindy T van Velthoven3, Rolf Gruetter2,4, Petra S Hppi1, Annemieke Kavelaars3, Cobi J. Heijnen3, Stphane V. Sizonenko1

1Division of Child Growth & Development, University of Geneva, Geneva, Switzerland; 2Laboratory for Functional & Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Lab. for Neuroimmunology & Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, Netherlands; 4Department of Radiology, Universities of Geneva & Lausanne, Geneva & Lausanne, Switzerland

Premature infants are at risk of white matter injury and altered development resulting in a chronic disturbance of myelination. Cerebral Hypoxia-Ischemia/Reperfusion in the premature infant represents a major cause for perinatal white matter injury. Recently, it has been shown that Mesenchymal Stem Cell (MSC) treatment after neonatal HI had neuroregenerative effects. The goal of this study was to assess the neuroregenerative effect of MSC treatment in neonatal mouse brain following HI by DTI derived parameters. This study confirmed white matter damages following neonatal HI on mouse brain as well as neuroregenerative effect of MSC on HI induced white matter damages.