Qin Qin1,2, Alan J. Huang2,3, Jun Hua1,2, Matthias J. P. van Osch4, Peter C. M. van Zijl1,2
1Radiology, Johns Hopkins University, Baltimore, MD, United States; 2F.M. Kirby Center, Kennedy Krieger Institute, Baltimore, MD, United States; 3Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; 4Radiology, Leiden University Medical Center, Leiden, Netherlands
3D GRASE acquisition is a natural choice for whole brain ASL perfusion mapping. In GRASE, however, a long echo train is often used that not only causes blurring but also leads to signal loss due to T2 decay during acquisition. An acquisition strategy that can achieve a sharper point spread function would require an echo train of length comparable to tissue T2. In this work, this is theoretically derived and subsequently demonstrated experimentally for whole brain perfusion mapping with both high resolution and high SNR efficiency.