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Abstract #4002

Dosage-Dependent Effects of Isoflurane on Cerebral Blood Flow in Rhesus Monkeys

Chun-Xia Li1, Sudeep Patel1, Eddie Auerbach2, Xiaodong Zhang1

1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; 2Center for MR Research, School of Medicine, University of Minnesota, Minneapolis, United States

Non-human primates were widely used as various disease models and examined under isoflurane anesthesia.Isoflurane is believed to increase the cerebral blood flow in general but the detailed effects in the monkey brain still remain unknown. In this study, the dosage effects of isoflurane (0.6 to 1.2 MAC) on CBF in the different brain regions of monkey brain were investigated with the continuous arterial-spin-labeling (CASL) technique.