Abstract #4045

Multimodal Investigations in Cognitively Normal Elderly with Different Types of Apolipoprotein E (ApoE) Genotype Polymorphism: Brain Volume, Diffusion Anisotropy, & Cerebral Blood Flow MRI Study

Min-Ji Kim¹, Geon-Ho Jahng¹, Sun-Mi Kim¹, Chang-Woo Ryu¹, Soo-Yeol Lee², Hack-Young Lee³, Won-Chul Shin³

¹Department of Radiology, Kyung Hee University Hospital-Gangdong, Kyung Hee University, Seoul, Korea, Republic of; ²Department of Biomedical Medical Engineering, Kyung Hee University; ³Department of Neurology, Kyung Hee University Hospital-Gangdong, Kyung Hee University, Seoul, Korea, Republic of

To evaluate brain cortical atrophy, on regional structure alternations, and cerebral perfusion change in cognitively normal (CN) elderly across the apoE genotype, we obtained 3D T1WI , DT-MRI and pulsed ASL-MRI in 37 CN subjects with carriers or non-carriers of the apoE4 including E2/E3, E3/E3 and E3/E4. Brain volumes, fractional anisotropy (FA)/trace and cerebral blood flow (CBF) were compared among the genotypes by ANOVA test. As compared to non-carriers, VBM demonstrated significantly brain atrophy in the apoE4 group. In carriers of the apoE4 genotype, FA value reduced. However, we did not found any significant differences in the CBF among the groups.