Min-Ji Kim1, Geon-Ho Jahng1, Sun-Mi Kim1, Chang-Woo Ryu1, Soo-Yeol Lee2, Hack-Young Lee3, Won-Chul Shin3
1Department of Radiology, Kyung Hee University Hospital-Gangdong, Kyung Hee University, Seoul, Korea, Republic of; 2Department of Biomedical Medical Engineering, Kyung Hee University; 3Department of Neurology, Kyung Hee University Hospital-Gangdong, Kyung Hee University, Seoul, Korea, Republic of
To evaluate brain cortical atrophy, on regional structure alternations, and cerebral perfusion change in cognitively normal (CN) elderly across the apoE genotype, we obtained 3D T1WI , DT-MRI and pulsed ASL-MRI in 37 CN subjects with carriers or non-carriers of the apoE4 including E2/E3, E3/E3 and E3/E4. Brain volumes, fractional anisotropy (FA)/trace and cerebral blood flow (CBF) were compared among the genotypes by ANOVA test. As compared to non-carriers, VBM demonstrated significantly brain atrophy in the apoE4 group. In carriers of the apoE4 genotype, FA value reduced. However, we did not found any significant differences in the CBF among the groups.