Eva Aufhaus1, Wolfgang Weber-Fahr1, Gunilla Oberthuer1, Mareen Hoerst1, Nuran Tunc-Skarka1, Markus Sack1, Andreas Meyer-Lindenberg2, Uwe Boettcher3, Gabriele Ende1
1Neuroimaging, Central Insitute of Mental Health, Mannheim, Germany; 2Psychiatry, Central Insitute of Mental Health, Mannheim, Germany; 3Siemens Medical, Erlangen, Germany
The MEGA-PRESS edited GABA signal still overlaps with co-edited macromolecule resonances. We investigated two methods of GABA editing using two different reflection frequencies and obtained spectra from the ACC (anterior cingulate cortex) in 49 healthy subjects. The mean GABA to H2O ratio obtained with the center frequency of the two editing pulses set to 1.7 ppm was only 44.8% of the ratio obtained with the center frequency set to 4.7 ppm. Only this smaller GABA signal was found to be negatively correlated with the co-edited glutamate signal.