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Abstract #4053

How Many Subjects Should Be Included in a Well-Powered Cross-Sectional Cortical Thickness Analysis?

Heath Richard Pardoe1, David F. Abbott1, Graeme D. Jackson1,2

1Brain Research Institute, Florey Neuroscience Institutes, Melbourne, Victoria, Australia; 2Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia

A critical aspect of study design is the inclusion of appropriate numbers of subjects. Standard methods for power analysis were applied on a vertex-wise basis to estimate how many subjects should be included in a cross-sectional MRI-based cortical thickness analysis to ensure the study is well powered. Based on results from a standard clinical MRI scanner, we found considerable heterogeneity in the minimum number of subjects required across the cortical sheet. Cortical thickness analyses of the temporal lobe require more subjects for a well-powered study than the frontal, parietal and occipital lobes.