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Abstract #4067

BOLD Activation Pattern for Motor Task in Chronic Stroke Patients After Administration of Autologous Mononuclear & Mesenchymal Stem Cells

Ashu Bhasin1, S. Senthil Kumaran2, M. V. Padma1, Sujata Mohanty3, Rohit Bhatia1

15 patients with chronic stroke received intracerebral autograft CD34+ stem cell implantation. The stem cells were labeled with supermagnetic nanoparticles which appeared as hypointensity on T2W gradient images. Longitudinal follow-up of the implanted nanoparticles with T2W gradient images were scheduled and mean R2 relaxivity of hypointense area at each time point was calculated. We found some of the injected magnetic nanoparticles which labeled on the stem cell can be detected on the T2W gradient images in the 6-month follow-up. The clearance patterns are associated with the relative injected location to the infracted lesion.

1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India; 2Department of N.M.R, All India Institute of Medical Sciences, Delhi, India; 3Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India