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Abstract #4073

USPIO High Resolution Neurovascular Imaging of Rat Middle Cerebral Artery Occlusion Stroke Model

Yimin Shen1, Weili Zheng1, Yu-Chung N. Cheng1, Yuchuan Ding2, Jean Sebastien Raynaud3, E. Mark Haacke1

1Radiology, Wayne State University, Detroit, MI, United States; 2Neurological Surgery, Wayne State University, Detroit, MI, United States; 3Guerbet, France

Our purpose is to determine if USPIO high resolution SWI at 7T sufficiently aid in visualization of collateral vessels in the penumbral area of lesions in a rat MCAO stroke model. Stroke in rats was induced by a 2-hour right MCAO using an intraluminal filament. MRI scans were performed on no stroke (n=1), stoke no treatment (n=5), stroke with sildenafil treatment rats (n=6) at four time points: baseline, 24h post MCAO, two weeks, four weeks. SWI shows clearly the presence of newly developed vessels near periphery of ischemic core in sildenafil treated severe stroke animals after two-week MCAO but not shows in mild stroke animals.