1Department of Radiology, Stanford University, Stanford, CA, United States; 2Department of Neuroradiology, Technische Universitaet Dresden, Dresden, Germany; 3Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; 4Department of Diagnostic Radiology & Nuclear Medicine, University of Western Ontario, London, Ontario, Canada; 5Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada; 6Brown University, Providence, RI, United States
Using the multi-component Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT) method, we examined the severity of demyelination in a variety of tissue compartments across a sample of controls and Multiple Sclerosis patients. We looked at traditional volumetric atrophy measures and sought to combine all these metrics to best predict EDSS (clinical disability score). Demyelination and atrophy had a stronger association with EDSS than lesion load. The severity of demyelination in any given tissue compartment was statistically different between controls and every patient class. Quantitative measures significantly improve the ability to predict EDSS above atrophy measures alone.